What is the main role of the Institutional Review Board (IRB) in clinical research?

The primary role of the Institutional Review Board (IRB) in clinical research is to oversee research involving human subjects. This involves evaluating the ethical aspects of research proposals to ensure the rights and welfare of participants are protected. The IRB reviews the study's design, informed consent processes, and ongoing monitoring to ensure that potential risks are minimized and that the research is ethically sound.

The IRB's responsibility is crucial for maintaining public trust in clinical research, as it serves as a safeguard against unethical practices. By requiring that studies adhere to ethical standards, the IRB helps to ensure that participants are treated with respect and that their participation is voluntary and informed. This function is fundamental to the integrity of clinical research, distinguishing it from other regulatory roles such as funding research studies or authorizing drug marketing.